About This Chapter
Below is a sample breakdown of the DNA Replication chapter into a 5-day school week. Based on the pace of your course, you may need to adapt the lesson plan to fit your needs.
|Day||Topics||Key Terms and Concepts Covered|
|Monday||Models of DNA replication||Experiments proving or disproving the semi-conservative, conservative and dispersive models of DNA replication|
|Tuesday||DNA helicase||DNA helicase's role in separating the parental and daughter strands of DNA to prepare for replication|
|Wednesday||DNA polymerase and RNA primase||RNA primase and the synthesis of RNA primer; DNA polymerase and the addition of daughter nucleotides|
|Thursday||Leading and lagging strands||Continuous and discontinous replication; the function of DNA ligase in joining together Okazaki fragments|
|Friday||DNA replication review||An overview of the roles DNA helicase, RNA primase, DNA polymerase and DNA ligase play in the replication process|
1. What Is DNA Replication? - Conservative, Semi-Conservative & Dispersive Models
How do we know that DNA replication is semi-conservative? How do we know it's not conservative or dispersive? Let's follow the famous experiment by Meselson and Stahl to find out!
2. How Helicase Unwinds the DNA Double Helix in Preparation for Replication
How does semi-conservative replication begin? Discover how DNA helicase creates a replication fork to unwind the complicated DNA molecule and allow daughter strands to form on the parental template.
3. How DNA Polymerase and RNA Primase Initiate DNA Replication
How do enzymes assist in starting DNA replication? In this lesson, we explore the work of a contributing enzyme, DNA polymerase, and learn how the RNA primer is made by the action of RNA primase.
4. DNA Replication: The Leading Strand and DNA Polymerase Activities
How does replication occur in the antiparallel DNA molecule? In this lesson, explore the significance of the leading and lagging strands, and learn how Okazaki fragments and RNA ligase make DNA replication possible.
5. DNA Replication: Review of Enzymes, Replication Bubbles & Leading and Lagging Strands
Feeling lost in the thorny details of DNA replication? This lesson provides an overview of semi-conservative replication, with a focus on putting together all of the concepts involved. We'll review the work of each enzyme on our way to completing the big picture of DNA replication.
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