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A 36-year-old man presents with fever, night sweats, weight loss, and a feeling of fullness in...

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A 36-year-old man presents with fever, night sweats, weight loss, and a feeling of fullness in his abdomen. Subsequent lymph node biopsy reveals a diagnosis of Non-Hodgkin lymphoma. Although lymphomas can originate in any of the lymphoid tissues of the body, most originate in the lymph nodes, and most (80-85%) are B-cell origin.

Hypothesize as to why B cells are more commonly affected than T cells.

Lymphoma:

Lymphoma is a type of hematopoietic cancer affecting lymphocytes (B and T cells) that has significant involvement of the lymph nodes. Many lymphomas arise due to chromosomal translocations that overexpress proto-oncogenes.

Answer and Explanation: 1

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The lymphoma bias towards B cells over T cells is likely due to genomic factors involved in antibody production in B cells. B cells undergo...

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What is Lymphoma? - Hodgkin's Lymphoma vs non-Hodgkin's

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Chapter 7 / Lesson 3
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There is a difference between Hodgkin's lymphoma and non-Hodgkin's lymphoma, but there is some common confusion over the two diseases. Learn more about the differences between Hodgkin's lymphoma and non-Hodgkin's lymphoma, discover what lymphoid tissue is, and explore lymphoma and its effects and classifications.


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