Does the collateral damage to cells in the event of chronic inflammation, have a protective mechanism?
Inflammation is a way of the immune system to respond to the foreign object in the body - a microorganism, a cancer cell or any other invader. This is a very complex process involving multiple stages of activation of the immune cells such as macrophages and implicates many ancillary molecules such as chemokines and cytokines.
Answer and Explanation: 1
Inflammation is meant to be a time-limited and site confined process that is supposed to cease after the elimination of the threat. In the case of the chronic inflammation, the inflammatory molecules and immune cells are building up and fail to undergo the inactivation. Sometimes injuries to tissues, tumors or autoimmune responses could keep the inflammation on for a long time and to produce the unwanted damage locally or systemically. In extreme cases, inflammation could destroy perfectly healthy tissues and negatively affect the normal functionality of organs as in the case of arthritis or inflammatory bowel disease. There are very limited possibilities for the body to deal with chronic inflammation and if left untreated it could have derogatory effects on the general health and the well being of the individual
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fromChapter 2 / Lesson 4
This lesson will discuss two important roles systemic inflammation is involved in: fever and leukocytosis. It will also discuss the flip-side, two bad components of systemic inflammation: cachexia and anaphylactic shock.