Explain how the intrinsic and extrinsic coagulation pathways are interrelated.


Explain how the intrinsic and extrinsic coagulation pathways are interrelated.

Intrinsic and Extrinsic Coagulation Pathways

The intrinsic and extrinsic coagulation pathways are essential components that stop the body from bleeding out when there is an injury to a blood vessel. Though they are different, they are both means of achieving the same goal.

Answer and Explanation: 1

The intrinsic pathway of coagulation begins with activation of factor 12, while the extrinsic pathway begins with tissue damage. Both pathways go through respective signalling pathways before activating factor 10. This is where the intrinsic and extrinsic pathways come together. Factor 10a (activated) activates prothrombin into thrombin, which in turn activates fibrinogen into fibrin. Fibrin, prothrombin, and platelets are responsible for creating a 'plug' at the site of injury that stops blood from leaving the blood vessel.

Therefore intrinsic and extrinsic pathways are interrelated from the steps following and including the activation of factor 10.

Learn more about this topic:

Blood Coagulation and Wound Healing


Chapter 6 / Lesson 18

After suffering a wound, the body does everything it can to promote blood clotting and, ultimately, wound healing. The general term hemostasis refers to the stoppage of bleeding, and it just one of the many factors, others being platelets and thromboxane A2, that are essential for proper wound healing. This lesson details the process of blood coagulation, from the clotting factors to the coagulation cascade.

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