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Outline all the steps in a possible synthesis of each of the following compounds from toluene and...

Question:

Outline all the steps in a possible synthesis of each of the following compounds from toluene and any needed aliphatic and inorganic reagents:

1.) phenylethanoic acid

2.) 4-methylbenzoic acid

Grignard Reaction:

The reaction of an alkyl bromide or aryl bromide with magnesium in an ethereal solvent gives a Grignard reagent. The Grignard reagent will react with carbon dioxide {eq}\rm (CO_2) {/eq} followed by acidic work-up to give a carboxylic acid.

Answer and Explanation: 1

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1.) The synthesis of phenylethanoic acid starting with toluene is given below.

Step 1: Radical bromination of toluene happens at the benzylic...

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The Grignard Reaction Mechanism
The Grignard Reaction Mechanism

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Chapter 10 / Lesson 25
13K

Have you ever wondered how carbon-carbon bonds are created in organic compounds? Continue reading to explore how these bonds are formed using a Grignard reaction. Identify the steps involved by learning about mechanism for this reaction.


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