What is the treatment for mast cell activation disorder?


What is the treatment for mast cell activation disorder?

The Mast Cell:

A mast cell is a type of white blood cell that originates from bone marrow. They hold many granules containing substances known as "mediators" that can be secreted when mast cells are stimulated. This leads to allergic and inflammatory body responses.

Answer and Explanation:

The treatment for mast cell activation syndrome includes several modalities, including:

  • H1 Histamine Receptor Blockers (hydroxyzine, diphenhydramine, cetirizine, loratadine, fexofenadine)
  • H2 Histamine Receptor Blockers (famotidine, cimetidine, ranitidine)
  • Leukotriene inhibitors (montelukast, zafirlukast)
  • Mast cell stabilizers (cromolyn, ketotifen)

Other natural antihistamine and mast cell stabilizers have been used including ascorbic acid (vitamin C), quercetin, vitamin B6 and

omega-3 fatty acids.

Mast cell activation syndrome (MCAS) is a condition with symptoms involving the skin, gastrointestinal, cardiovascular, respiratory, and neurologic systems. It can be classified into primary (proliferation), secondary (specific stimulus), and idiopathic (no identifiable cause).

The symptoms of this disorder include:

  • Skin rashes/hives
  • Swelling/edema
  • Flushing
  • Itching
  • Nausea/vomiting
  • Diarrhea
  • Wheezing
  • Shortness of breath
  • Heart palpitations
  • Anxiety, difficulty concentrating
  • Fatigue

Medical Disclaimer: The information on this site is for your information only and is not a substitute for professional medical advice.

Learn more about this topic:

The Inflammatory Response's Effect on the Entire Body


Chapter 2 / Lesson 4

This lesson will discuss two important roles systemic inflammation is involved in: fever and leukocytosis. It will also discuss the flip-side, two bad components of systemic inflammation: cachexia and anaphylactic shock.

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