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Mutation & DNA Damage Chapter Exam

Exam Instructions:

Choose your answers to the questions and click 'Next' to see the next set of questions. You can skip questions if you would like and come back to them later with the yellow "Go To First Skipped Question" button. When you have completed the practice exam, a green submit button will appear. Click it to see your results. Good luck!

Page 1

Question 1 1. If no sister chromatids or homologous chromosomes are available, then what type of double-strand break repair would a cell need to use?

Question 2 2. What is a Holliday junction?

Question 3 3. _____ mutations result in a longer DNA strand.

Question 4 4. The best term to describe the incorporation of a random mistake into the DNA sequence at a specific point is _____.

Question 5 5. Why is it important for the mismatch repair machinery to tell the difference between the parental strand and the new strand of DNA?

Page 2

Question 6 6. Why are methyl (CH3) groups important in mismatch repair?

Question 7 7. Which of these statements about pyrimidine dimers is TRUE?

Question 8 8. Which of these best describes the differences between ionizing and non-ionizing radiation?

Question 9 9. Which of the following statements about tumor suppressor genes is TRUE?

Question 10 10. Which of the following statements about retinoblastoma is TRUE?

Page 3

Question 11 11. Which of the following is NOT a carcinogen?

Question 12 12. Why is promotion reversible if it is stopped early enough in the process?

Question 13 13. What kind of mutation causes sickle-cell anemia?

Question 14 14. The eleventh amino acid of protein X should be serine, however due to a mutation it now has the amino acid alanine in that position. Which type of mutation could have caused this change?

Question 15 15. Imagine that you are a cell in the body and you notice the cell next to you is suddenly behaving rather oddly. It is growing and looks like it's going to divide when no signal has been given to do so. The immune cells nearby don't seem to notice anything strange even when you send out distress signals. You also stop sending your survival signals to it to see what it does, and there's no effect. What is probably happening to the cell?

Page 4

Question 16 16. Cell suicide or programmed cell death is called what?

Question 17 17. The deletion of a base in the DNA strand will _____.

Question 18 18. How would a shift in the reading frame likely alter the resulting protein?

Question 19 19. How can base analogs cause mutations?

Question 20 20. Which type of mutagen is most likely to cause frameshift mutations?

Page 5

Question 21 21. What is the main problem with current treatments for cancer like chemotherapy?

Question 22 22. What causes tumors to form?

Question 23 23. What is the relationship between a base and a nucleotide?

Question 24 24. Nucleotide excision repair recognises which type of faults in DNA?

Question 25 25. Which type of double-strand break repair is the most likely to cause deletions or changes in the DNA sequence?

Page 6

Question 26 26. Based on the original sequence, ACTTGAC, which of the following answer choices includes a transition mutation?

Question 27 27. How does the mismatch repair machinery recognize an error in DNA?

Question 28 28. Which type of radiation is LEAST likely to cause mutations in cells deep inside of the body?

Question 29 29. Why is retinoblastoma protein important?

Question 30 30. Substances that exist in the world which cause cancer are known as _____.

Mutation & DNA Damage Chapter Exam Instructions

Choose your answers to the questions and click 'Next' to see the next set of questions. You can skip questions if you would like and come back to them later with the yellow "Go To First Skipped Question" button. When you have completed the practice exam, a green submit button will appear. Click it to see your results. Good luck!

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