Praxis Biology: Human Genetics Chapter Exam

Exam Instructions:

Choose your answers to the questions and click 'Next' to see the next set of questions. You can skip questions if you would like and come back to them later with the yellow "Go To First Skipped Question" button. When you have completed the practice exam, a green submit button will appear. Click it to see your results. Good luck!

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Question 1 1. In a person who inherits one dysfunctional copy of the RB1 gene from one of their parents, how many times does loss of heterozygosity of the RB1 gene have to happen in order to form a tumor?

Question 2 2. Generally speaking, what are the odds that an autosomal dominant condition will be passed from an affected individual to their child?

Question 3 3. What amino acid does the CAG codon code for?

Question 4 4. A geneticist is studying a rare, autosomal dominant syndrome that is characterized by the following three hallmarks: a significantly increased risk for cancer, exceptional height, and early hearing loss. If the syndrome is 70% penetrant, then what does this mean?

Question 5 5. Which of the following statements BEST explains loss of heterozygosity?

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Question 6 6. Hereditary Breast and Ovarian Cancer Syndrome (HBOC) _____.

Question 7 7. The progressive loss of cognitive capabilities is called what?

Question 8 8. How does Tay-Sachs Disease progress?

Question 9 9. Which of the following statements about multifactorial traits is TRUE?

Question 10 10. If an HTT allele contains 32 CAG repeats and produces a normally functioning protein, how is it that a child of the person who has this allele can develop Huntington's Disease even though neither of the parents had Huntington's Disease?

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Question 11 11. All of the following statements about the triangle symbol are true EXCEPT:

Question 12 12. What is the most likely type of inheritance for the genetic condition shown in this pedigree?

Question 13 13. What is a syndrome?

Question 14 14. A couple has three children: a 14-year-old daughter and two sons, ages 10 and 12. If the mother and daughter are both known to have a genetic disorder, what would the pedigree of this family look like?

Question 15 15. What is the most likely type of inheritance for the genetic condition shown in this pedigree?

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Question 16 16. Which of the following statements about retinoblastoma is TRUE?

Question 17 17. Why is Tay-Sachs disease recessive?

Question 18 18. A disorder characterized by the inheritance of genetic mutations that increase the risk for development, especially early development, of a cancer is called:

Question 19 19. Which of these is NOT a clue for a family cancer syndrome?

Question 20 20. What do we call a situation where a single copy of a functional gene is not enough to maintain normal function?

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Question 21 21. Which of the following statements about the proband is TRUE?

Question 22 22. In the following pedigree, how many male cousins does the proband have?

Question 23 23. When collecting samples to study the genetics of a complex disease, which of the following factors would you NOT want to be equally represented in both the affected and unaffected groups?

Question 24 24. Why are there not any well-known, highly penetrant, dominant disorders that are lethal before sexual maturity?

Question 25 25. If this is a pedigree for a family with a history of hemophilia, which is a sex-linked condition, what do we know about the proband's mother?

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Question 26 26. A geneticist is studying a genetic condition. They determine that the causative gene for this particular condition is located on human chromosome 2. What can we conclude about the condition? Why?

Question 27 27. The extent to which a trait or condition is expressed is called:

Question 28 28. Why is retinoblastoma protein important?

Question 29 29. Jake has hemophilia B. He marries Melissa who is not a hemophiliac and is not a carrier. What are the odds of being a hemophiliac for each of their children?

Question 30 30. Li-Fraumeni syndrome arises from a mutation in _____.

Praxis Biology: Human Genetics Chapter Exam Instructions

Choose your answers to the questions and click 'Next' to see the next set of questions. You can skip questions if you would like and come back to them later with the yellow "Go To First Skipped Question" button. When you have completed the practice exam, a green submit button will appear. Click it to see your results. Good luck!

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