Antibodies: Their Important Structure

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  • 0:05 Antibody Structure
  • 0:42 Chains and Domains
  • 2:23 Paratope and Epitope
  • 5:16 Lesson Summary
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Lesson Transcript
Instructor: Artem Cheprasov
This lesson will cover the basic but important structural components and sites of an antibody as well as their function. This includes heavy chains, light chains, variable domains, constant domains, paratopes, and epitopes.

Antibody Structure

Antibodies are little glycoprotein molecules that are the major components of the humoral immune system. They aren't just little globs of nothing, however. They are highly specialized structures created to go after very specific invaders in your body. If it wasn't for antibodies and their unique shape, we'd have a very hard time fighting off disease.

Chains and Domains

To me, antibodies, also called immunoglobulins, sort of look like one of those old-fashioned dowsing rods people believe can help find water. While antibodies don't find water, they do find specific pathogens thanks to their unique structure. Each Y-shaped antibody is made up of four chains of protein. There are two heavy chains and two light chains that are, once again, polypeptides that combine to form an antibody.

Each part of a chain, heavy or light, has what's known as a constant domain. This is the part of the antibody that is the same across a unique isotype of immunoglobulin. An isotype is just a different variation of antibody. Therefore, each isotype of immunoglobulin would have a different constant domain in its heavy chain. However, there needs to be variation within an isotype of immunoglobulin for maximal effectiveness of your immune system.

Therefore, each part of every light and heavy chain has what's known as the variable domain. This is the region located at the end of the light and heavy chains of an antibody. This region allows for each individual isotype of antibody to be very specific to a type of antigen. This means that when a white blood cell, called a plasma cell, produces an antibody for a specific pathogen, it will alter the variable region such that the antibody will be able to attach to a very specific pathogen, but not another.

Paratope and Epitope

Let's use an example to solidify what I mean. Any type of foreign substance in your body, such as a virus, bacteria, fungi, toxins, drugs, and so forth, can trigger a very similar response. But we'll focus on bacteria for now.

If a bacterium, a Lego piece, enters your body, it's bound to have a surface receptor on it. The receptors are like those little round things sticking off the top of the Lego pieces. These receptors are used by the bacterium to communicate, eat, and so forth. However, these receptors can also be used by our immune system.

Our body isn't a bacterium; it's not made up of Legos. Hence, it probably won't have the same receptors as a bacterium. Therefore, components unique to that bacterium, such as its receptors, can be used by our immune system as a signal to destroy the bacterium.

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