Bubonic & Pneumonic Plague: Disease Caused by Yersinia pestis

Lesson Transcript
Instructor: Angela Hartsock

Angela has taught college microbiology and anatomy & physiology, has a doctoral degree in microbiology, and has worked as a post-doctoral research scholar for Pittsburgh’s National Energy Technology Laboratory.

Most students learn about plague in history class due its huge impact on human history. In this, the first of two lessons on plague, we will look at the disease from a microbiological perspective, focusing on the causative agent: Yersinia pestis.

Biological Weapon of Choice in the 1300s

Imagine you were born in the early 1300s in the Black Sea port city of Caffa, part of today's Ukraine. Usually, Caffa is a bustling port, full of people and goods from the far reaches of Europe and Asia. But today has an ominous air. A group of Italian merchants has unwisely crossed the Mongols, who have controlled the area for generations. You know that nothing good can come of this. The merchants feel safe, holed up within the walls of Caffa. Then, you hear the screams coming from inside the city, and you start to smell the stench.

Suddenly, something large flies over the wall, landing a few feet from where you're standing. Now the stench is unbearable. You look closer at the projectile and recoil in horror. It's a dead human body. The Mongols are catapulting dead humans over the walls of Caffa! In order to drive out the merchants, the Mongols have started raining infectious death over the entire city.

This is one of the earliest confirmed cases of a biological agent used as a weapon. Each of those bodies carries billions of tiny bacteria capable of incredible amounts of destruction. The Mongol weapon of choice is Yersinia pestis, the bacterium that causes plague.

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  • 0:05 Biological Weapon of…
  • 1:23 Yersinia pestis and…
  • 3:27 Plague
  • 5:22 3 Types of Plague
  • 6:04 Prevention
  • 6:36 Lesson Summary
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Yersinia pestis and the Rat Flea

Yersinia pestis is a small, Gram-negative, rod-shaped bacteria that causes plague. 'Gram-negative' refers to Yersinia having a cell wall with a thin peptidoglycan layer and an outer membrane, making these cells appear red in the classic Gram stain. Interestingly, with a careful staining procedure, Yersinia cells stain very heavily on each end and take up very little stain at the center, giving the cells a unique 'safety pin' appearance.

Yersinia pestis is a natural pathogen of rats. Most rats that carry the bacteria develop plague and die very quickly. There are a small percentage of rats, though, that are immune to plague. These rats become chronic carriers, capable of spreading the disease to many other rats, rodents, mammals, and even humans. But, it is not the rat you have to fear. It is actually another parasite living on the rat that transmits plague: the rat flea.

If rats are considered the natural host of Yersinia pestis, rat fleas are considered a plague vector. A vector is an organism that transmits a disease from an infected host to a susceptible host. When a rat flea bites an infected rat, it ingests the Yersinia bacteria in the rat's blood. Once in the flea's stomach, Yersinia has a fascinating mechanism for spreading itself to other hosts. The bacteria multiply, making millions of copies of itself, which eventually blocks the flea's digestive system.

Unable to swallow the blood it feeds on, the increasingly hungry flea becomes a ravenous biter. It attempts to feed on any warm-blooded animal it can reach, switching hosts frequently as it searches for a blood meal it can actually swallow. Every time it bites, it swallows some blood, but since the flea's stomach is so full of bacteria, it vomits up the blood along with some Yersinia cells. The cells get injected right into the new host. Every host is left with an itchy, red bite and a plague-inducing inoculation of Yersinia pestis.


'Plague' is the name given to any disease caused by the bacterium Yersinia pestis. Plague is considered one of the few history-changing diseases, killing hundreds of millions of people in the last 1,500 years.

The first major pandemic occurred in the 6th century AD. It began in Africa and spread to the entire Mediterranean basin. Estimates of this pandemic alone put the death toll at about 100 million, helping to contribute to the fall of the Roman Empire. In the 1300s, the more infamous 'Great Plague,' also known as the 'Black Death' pandemic, started in China, eventually reaching Europe. Over the next several hundred years, plague decimated the population of Europe, killing between 25-33% of the population of the continent with every new outbreak.

Some outbreaks claimed upwards of 60 million lives, leaving too few healthy laborers to even bury the dead, let alone providing for daily needs of the survivors. The last great pandemic started in the late 1800s, spreading from Asia in rat-infested ships. By 1900, some of those rats had reached San Francisco, depositing Yersinia pestis in the New World.

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