Celecoxib: Contraindications, Indications & Drug Interactions

Instructor: Artem Cheprasov

Artem has a doctor of veterinary medicine degree.

This lesson goes over the contraindications and indications of a drug called celecoxib. You'll also learn about some example drug interactions between this drug and others.


Too much of a good thing can be bad, if not, really bad. Eating too many fruits all at once can actually cause diarrhea. Too much caffeine can make us jittery and unable to sleep. Too much exercise can hurt our muscles and joints. You probably get the idea here.

Well, too much of a pain reliever or several pain relievers all at once can be a very bad thing. Yeah, it might help relieve your pain in the short term, but it might also end in your death, which ironically may be quite painful in this case. How so? Find out on this lesson on a drug called celecoxib, better known as Celebrex, as we go over its major indications, contraindications, and drug interactions.


Celecoxib is a pain reliever of a drug class generally known as NSAIDs, or non-steroidal anti-inflammatory drugs. It's used for several main issues. The first of which goes back to our introduction of too much exercise actually. When you over-exercise, you end up damaging your joints. This speeds up the destruction of your joint cartilage. This, in turn, leads to a form of arthritis (inflammation of the joints) known as osteoarthritis. You can think of osteoarthritis as 'wear and tear' arthritis.

Celecoxib can also be used to help manage another kind of arthritis, that of rheumatoid arthritis. This is an autoimmune form of arthritis. Autoimmune means that the body's immune system attacks the self ('auto-').

There's also a third kind of arthritis that celecoxib can be used for. This one is called ankylosing spondylitis. This is a form of arthritis that mainly affects the spine. In this kind of arthritis, bony bridges form between the spinal bones, fusing them to one another.

Finally, another major use of celecoxib is for the treatment of dysmenorrhea, which is a fancy word for menstrual pain/cramps.


Despite its many indications, or uses, celecoxib does have its contraindications, or instances when it shouldn't be used unless otherwise OK'd by your doctor.

The major contraindications of celecoxib include the following:

  • A known allergy to celecoxib
  • A known allergy to aspirin or another NSAID
  • Chronic hepatitis. This is a term for the persistent inflammation of the liver. This might be caused by something like a viral infection.
  • Around the time of coronary artery bypass graft surgery.

And, there's one last major one: unless directed otherwise by a doctor, celecoxib shouldn't be used at the same time as any other NSAID or steroid. That's because too much of a good thing can be bad. While all of these drugs can relieve a person's pain, when used together, they can potentially interact in a deadly manner which may lead to painful kidney failure, a really painful deadly hole in the intestinal tract, or other horrific complications.

Drug Interactions

This medication has hundreds of drug interactions. We can't cover all of them but here is a sample of them to give you an idea of the many issues that might occur when celecoxib is used improperly alongside another medication.

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