Denaturation of Protein: Definition & Causes

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  • 0:01 What is Protein Denaturation?
  • 1:10 Primary Structure
  • 2:05 Secondary Structure
  • 2:55 Tertiary & Quaternary…
  • 3:22 How Proteins Are Denatured
  • 4:52 Lesson Summary
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Lesson Transcript
Instructor: Derrick Arrington

Derrick has taught biology and chemistry at both the high school and college level. He has a master's degree in science education.

Proteins are found in all living organisms. Problems occur when proteins become denatured. In this lesson, you will learn about a change in proteins known as denaturation.

What Is Protein Denaturation?

Living organisms require many types of large molecules in order to survive. Very few of these molecules serve as many purposes as proteins. Proteins are large molecules composed of folded chains of amino acids. Every protein has a unique shape and that shape determines the things it does. You could think of them as keys that fit into certain locks around the body.

Proteins do lots of different things around the body, including speeding up biological processes, recognizing antibodies, providing structure to certain body parts, transporting substances, regulating genes, and responding to signals inside and outside the body.

Proteins range in size from small ones, such as insulin - only 51 amino acids long, to extremely large ones, such as titin - almost 27,000 amino acids long. No matter their size, they must be folded into a particular shape in order to function. Sometimes, though, things go wrong and cause the protein to unfold. Denaturation is the process by which proteins lose their folded structure and cease to function.

The Structure of Proteins: Primary Structure

Before we tackle denaturation, let's look closer at the structure of proteins. Every protein has four levels of structure which scientists refer to. The four levels are primary, secondary, tertiary, and quaternary.

The primary structure of a protein is the sequence of amino acids that form that protein. Every protein has a unique sequence of amino acids linked together in a long chain. If the amino acids are out of order, the protein will not function properly.

For example, insulin has a chain which begins with the amino acid glycine, followed by isoleucine, valine, and glutamic acid. The chain continues, but you get the idea. If any members of this chain are out of order - for example, if the glycine was switched with the valine, then the resulting chain wouldn't combine to insulin. It's only because the amino acids are linked this way that insulin is created.

The Structure of Proteins: Secondary Structure

The secondary structure of a protein refers to regular repeated patterns in the folding of amino acid chains. Remember, these long chains fold into specific shapes depending on the protein; secondary structure identifies patterns in these folds. There are two types of folding at this level: alpha helixes and beta sheets.

An alpha helix is a spiral coil shape formed by hydrogen bonds between amino acids of the same chain. These bonds cause the chain to curve back around in this spiral pattern.

An image of a protein.

Beta sheets are formed when two amino acid chains align, and the acids of these two chains form hydrogen bonds with one another. These bonds cause the two chains to run parallel to each other and form a flat or wrinkled pattern.

An image of a protein.

The Structure of Proteins: Tertiary and Quaternary Structures

The tertiary structure of a protein describes the specific geometric shape of that protein, or the structure which results from all the alpha helixes and beta sheets of its amino acid chains.

Many proteins are constructed from two folded amino acid chain subunits that come together to form one final protein. The quaternary structure describes the way the position of these amino acid chain subunits relate to each other.

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