Food Poisoning from Clostridium perfringens & Clostridium Perfringens Enterotoxin

Food Poisoning from Clostridium perfringens & Clostridium Perfringens Enterotoxin
Coming up next: What Is Cholera? - Disease Symptoms and Vibrio Cholerae

You're on a roll. Keep up the good work!

Take Quiz Watch Next Lesson
 Replay
Your next lesson will play in 10 seconds
  • 0:05 Deadly Psychiatric…
  • 1:29 Clostridium perfringens
  • 4:00 C. perfringens Food Poisoning
  • 6:28 Diagnosis and Treatment
  • 7:25 Prevention
  • 8:26 Lesson Summary
Add to Add to Add to

Want to watch this again later?

Log in or sign up to add this lesson to a Custom Course.

Log in or Sign up

Timeline
Autoplay
Autoplay
Speed

Recommended Lessons and Courses for You

Lesson Transcript
Instructor: Angela Hartsock

Angela has taught college Microbiology and has a doctoral degree in Microbiology.

Clostridium perfringens is a common soil bacteria that causes a mild case of food poisoning. In this lesson, we will look at one particularly severe outbreak and the factors leading to the higher-than-normal number of deaths that occurred.

Deadly Psychiatric Hospital Outbreak

In 2010, at a psychiatric hospital in Louisiana, several unlikely variables aligned, leading to a severe outbreak of food poisoning caused by Clostridium perfringens. In total, 54 patients and staff developed symptoms and three died. This might not sound too bad. Three out of 54 is only 5.5%. There are other foodborne illnesses, like typhoid fever for example, with death rates between 15-20%.

But, what if I told you that C. perfringens usually only kills less than 0.03% of those infected? Out of 54, only 0.016 of a person would have been expected to die, or, in other words, you could reasonably have expected no deaths due to this outbreak. If you suspect that other factors must have been involved, you would be right.

Like I mentioned earlier, this outbreak was a perfect storm in which several very unlikely situations all occurred at the same time, compounding the illness. In this lesson, we will explore the bacterium Clostridium perfringens using this outbreak as a backdrop to learn why it was so much deadlier than your typical C. perfringens food poisoning outbreak.

Clostridium perfringens

Let's start with the bacterium itself. Clostridium perfringens is a Gram-positive, obligate anaerobic, endospore-forming, rod-shaped bacteria. Whoa, that's a mouthful! Let's look at each term individually. 'Gram-positive' refers to the thick layer of peptidoglycan present in the bacterial cell wall, making these cells appear purple in the classic Gram stain.

An obligate anaerobe is a bacterium that cannot survive in the presence of oxygen, but since C. perfringens is an endospore-former, it is able to form highly resistant endospores. So, if the cells are exposed to oxygen, they will die, but the endospores will survive. These endospores can also survive drying out, high temperatures and exposure to many common household cleaners.

C. perfringens is commonly found in soil, but small populations are able to survive in the intestines of animals. As a result, the bacteria are also present in sewage. Most people catch C. perfringens by eating meat contaminated with feces containing the bacteria. C. perfringens grows best in protein-rich, low oxygen environments, like those present in precooked or dried meat and fish. In the case of the psychiatric hospital outbreak, the source of the bacteria was found to be the chicken served at dinner the night before the outbreak.

The first of our unique conditions emerges here. The chicken had been cooked the day before it was served and allowed to slowly cool over the next 24 hours. These are the perfect conditions for C. perfringens. Cooking killed the actively growing bacteria but not the endospores. C. perfringens outbreaks usually occur in large facilities where food is prepared in large batches, like hospitals, prisons and cafeterias. The large amount of food cooked in one pot shields some of the endospores from temperatures high enough to kill them.

After cooking, the chicken was covered and refrigerated in large pans, but the huge bulk of food slowed the cooling. Once the chicken cooled below 140 degrees Fahrenheit, the endospores germinated, and the bacteria multiplied very rapidly. Making matters worse, on three separate occasions, chicken was removed from the pans and allowed to warm up to room temperature, but it was not recooked while employees cut pieces off for sandwiches. This likely led to more contamination and brief bouts of rapid bacterial growth as the food's temperature temporarily increased.

C. perfringens Food Poisoning

So, now we have a large batch of chicken full of actively growing bacteria as a result of being poorly handled and prepared. Let's take a quick look at what the bacteria do to the body. First of all, a patient must consume a massive amount of C. perfringens cells before symptoms will develop, upwards of 100 million cells.

Your gastrointestinal tract is not a favorable environment for C. perfringens growth, so the bacteria form endospores to ride out the poor growth conditions. This is where the problems start. During the sporulation process, C. perfringens releases an enterotoxin into your intestine.

An enterotoxin is a toxin that is active in the gastrointestinal tract of a host. The enterotoxin makes the intestinal lining much more permeable to water, resulting in an increased flow of water into the intestine. What results is Clostridium perfringens food poisoning. Remember, in food poisoning, the symptoms are a result of preformed microbial toxins, in this case C. perfringens enterotoxin, not actively growing bacteria.

Within 8-12 hours, a patient will start experiencing diarrhea and abdominal cramping. The symptoms usually resolve without treatment in about 24 hours. In very young and very old patients, the diarrhea can be more severe, lasting 1-2 weeks, and these patients can die from dehydration complications. But, even in high-risk patients, fatalities are very rare.

At this point, several more compounding factors are revealed in the Louisiana outbreak. Since this outbreak occurred in a hospital, many of the patients were older and on medication - therefore, they were already at higher risk for complications. It turns out all three patients that died were older adults on medications that slowed the gastrointestinal tract. Now we have a deadly combination of an enterotoxin that causes increased water in the intestines and abnormally slow movement through the gut.

To unlock this lesson you must be a Study.com Member.
Create your account

Register to view this lesson

Are you a student or a teacher?

Unlock Your Education

See for yourself why 30 million people use Study.com

Become a Study.com member and start learning now.
Become a Member  Back
What teachers are saying about Study.com
Try it risk-free for 30 days

Earning College Credit

Did you know… We have over 200 college courses that prepare you to earn credit by exam that is accepted by over 1,500 colleges and universities. You can test out of the first two years of college and save thousands off your degree. Anyone can earn credit-by-exam regardless of age or education level.

To learn more, visit our Earning Credit Page

Transferring credit to the school of your choice

Not sure what college you want to attend yet? Study.com has thousands of articles about every imaginable degree, area of study and career path that can help you find the school that's right for you.

Create an account to start this course today
Try it risk-free for 30 days!
Create An Account
Support