Nomenclature of Skin Lesions: Primary Lesions

Lesson Transcript
Instructor: Rachel Torrens

Rachel obtained a Bachelor of Science in Biology from Grove City College. She then earned her Bachelor's and Master's Degree in Nursing from Thomas Jefferson University. For over 8 years, Rachel has practiced as a Board Certified Family Nurse Practitioner, and taught science to elementary aged students.

Abnormal skin growths are known as skin lesions, manifesting in dozens of different ways, and are organized into primary (disease) and secondary (external damage). Explore the layers of the skin, and learn the names and appearance of several common skin lesions. Updated: 11/03/2021

What Are Primary & Secondary Skin Lesions?

I'm sure you remember that revolutionary moment in your health science class when you learned the answer to this question - 'What is the largest organ?' The skin, that's right! Some of the wonder may have rubbed off by now, but the skin is truly an amazing, living organ. And it is busy! Constantly renewing itself and repairing damages.

Unfortunately, there are some things the skin cannot repair completely; otherwise, we'd all be walking around with baby smooth skin and the cosmetics industry would be out of business! Any abnormal growth or area of skin that differs from the skin around it is termed a skin lesion, often referred to by medical professionals as 'a lesion' for short.

There are many types of skin lesions found in hundreds of varying skin ailments. However, all skin lesions can be divided roughly into two categories: primary and secondary. Primary skin lesions are those lesions which are the direct result of a disease. These include macules, papules, nodules, plaques, vesicles, bullae, pustules, and wheals. Secondary skin lesions are those lesions that result from an outside force affecting the skin, such as scratching, or an evolutionary change in a primary lesion. Some of which include scale, crust, atrophy, erosion, ulceration, lichenification, fissure, laceration, and purpura.

The distinction between the two categories is not always clear. However, if an individual is able to appropriately label a skin lesion, then he is already halfway towards making the appropriate diagnosis. This is the power of terminology!

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  • 0:01 What Are Primary &…
  • 1:58 Layers of the Skin
  • 2:25 Macules, Papules,…
  • 4:29 Vesicles, Bullae,…
  • 6:36 Tumors, Cysts, & Abscesses
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Layers of the Skin

We are going to tackle primary skin lesions in this lesson. But before we do, let's quickly review the layers that make up the skin, as many of the definitions are based upon this information. The top most layer, represented by numbers one and two, is termed the epidermis. The next layer, labeled three, represents the dermis; and finally, at the base, labeled four, is the subcutaneous tissue.

Skin Layers

Macules, Papules, Nodules, and Plaques

We'll begin with some of the most common primary lesions: macules, papules, nodules, and plaques. A macule refers to a flat, clearly-defined lesion that is different in color from the surrounding skin, measuring less than one centimeter in diameter. If you closed your eyes and gently ran the pad of your finger over the affected skin, you would not know there was an abnormality. So, a freckle, for example, is a macule.

A papule, on the other hand, is a clearly-defined, solid lesion that is raised, measuring less than one centimeter in diameter. The 'bump' on this person's nose would be referred to as a papule:


So, a macule is a papule's cousin in a way. Both are small in size and clearly defined, but a macule is completely flat. A helpful way to remember this difference is that a lesion that got run over by a Mack truck would be completely flat, and thus it is a macule!

Now, it's time to meet papule's big brother, the nodule. A nodule is a solid, firm lesion, measuring more than one centimeter in diameter, which may be located in the epidermis, dermis, or subcutaneous tissue of the skin. So, again, a papule and a nodule are similar in that they are solid, firm lesions, but a nodule is larger. Furthermore, a nodule is not necessarily on the surface layer of the skin like a papule but may be deeper inside the tissue. For example, this woman has a nodule on her thyroid:


In order to feel the nodule, you would need to press down gently on the skin.

A plaque is a well-defined, raised, solid lesion that has a flat top and measures over one centimeter in diameter. In the land of skin topography, a plaque would be analogous to a plateau. Plaques are most commonly found in pathological conditions of the skin, such as eczema or psoriasis.

Vesicles, Bullae, Pustules, and Wheals

Next, we'll discuss vesicles, bullae, pustules, and wheals. And believe it or not, most of these lesions you've probably experienced yourself! A vesicle is a raised lesion, measuring less than one centimeter in diameter on the surface of the skin, filled with a clear fluid. 'Clear' in medical jargon is 'serous,' so you may hear this in some definitions. Does this sound familiar? Well, if you've ever had a blister on the back of your heel, then you've had a vesicle. And although most children are immunized against it these days, chicken pox is another example of vesicles forming on the skin.

A bulla (plural bullae) is a raised lesion, measuring more than one centimeter, filled with clear fluid. In other words, it's a vesicle's big sister. These can happen sometimes with allergic skin rashes, such as poison ivy or following a severe sunburn, you may develop blisters that are really large. These would be termed bullae.

A pustule is a raised lesion, measuring less than one centimeter on the surface of the skin, filled with pus. Can you guess which example I'm going to give? That's right! A pimple is a perfect example of a pustule. And even newborns experience acne. As you can see in this photo, the baby has a cluster of pustules on the left cheek:

ance on a baby face

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Nomenclature of Skin Lesions: Primary Lesions Quiz

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Which of type of skin lesion is most often found only in skin disorders such as eczema or psoriasis?

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