Overview of Psychiatric Drugs: History, Types & Uses

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  • 0:04 Psychiatric Medications
  • 1:10 Antidepressants
  • 2:25 Antipsychotics
  • 3:50 Lithium
  • 4:54 Lesson Summary
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Lesson Transcript
Instructor: Paul Bautista
Have you ever been curious about how psychiatric drugs work, or more specifically, which psychiatric drugs are used for which disorders? This lesson outlines some common psychiatric disorders and how various medications are used to treat and subdue psychotic symptoms.

We usually think of medicine as intended to cure specific physical symptoms; painkillers to help a headache, antibiotics to cure an infection like strep throat. So how can drugs be designed to affect the mind, achieving specific results like making someone less depressed, or getting rid of hallucinations?

Like many medicines, the earliest kinds of psychiatric medications were discovered largely by accident. The first antidepressants were intended as treatments for tuberculosis; the first antipsychotics were developed as anesthetics to use during surgery. These medications were found to improve mental functioning by changing brain chemistry in a variety of ways. In general, they change levels of neurotransmitters in the brain. Neurotransmitters are chemicals in the brain that allow brain cells, called neurons, to communicate with each other. Psychologists have noticed that the amounts of certain neurotransmitters in the brains of people with certain disorders are different than in healthy people's brains, leading to the development of drugs that aim to correct these imbalances.

Antidepressants change the levels of the neurotransmitters norepinephrine and serotonin which affect emotion and mood. There are three basic kinds of antidepressants, called MAOIs (Monoamine Oxidase Inhibitors), tricyclics and SSRI's (Selective Serotonin Reuptake Inhibitors). They all function a little differently. MAOIs and tricyclics raise both norepinephrine AND serotonin levels. SSRIs raise ONLY the levels of serotonin in the brain. This creates fewer side effects than MAOIs or tricyclics, though it does increase sexual side effects like lack of desire and erectile dysfunction. MAOIs have the worst side effects, which is why scientists kept working to make the newer kinds of antidepressants. People who take them must be careful to avoid foods that contain the chemical tyramine. Can you guess what kinds of foods contain tyramine? THE BEST KINDS - beer, some cheeses, cured meats. And if a person messes up and eats these foods anyway, it can produce a fatal interaction with the MAOI. These drugs are usually only recommended to people whose bodies can't tolerate the newer antidepressants.

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