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Renin Angiotensin Aldosterone System (RAAS): Pathway, Functions & Terms

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  • 0:05 The Control of Blood Pressure
  • 2:26 Angiotensinogen &…
  • 4:28 Control of the GFR
  • 6:11 Aldosterone & ADH
  • 7:48 Negative Feedback…
  • 10:36 Lesson Summary
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Lesson Transcript
Instructor
Artem Cheprasov

Artem has a doctor of veterinary medicine degree.

Expert Contributor
Maria Airth

Maria has a Doctorate of Education and over 20 years of experience teaching psychology and math related courses at the university level.

The renin-angiotensin-aldosterone system is one of the most complex and important systems in controlling the blood pressure in your body. As we go over this system, you'll also learn about the many hormones involved in the control of your body's glomerular filtration rate and blood pressure.

The Control of Blood Pressure

I'm pretty sure you have seen or heard a commercial touting a new drug that helps to regulate something known as systemic hypertension, or high blood pressure all over the body. Your body has an entire system that regulates blood pressure as well. It is actually built to counteract low blood pressure, or hypotension, instead of hypertension. You'll find out in this lesson that the main ways by which we can increase blood pressure is by constricting our blood vessels, increasing the amount of fluid in them, or both. Our body has a great way of doing the latter. Let's see how.

The Renin-Angiotensin-Aldosterone System (RAAS)

The smaller system that controls blood pressure is the tubuloglomerular feedback system.
Tubuloglomerular Feedback

Your body has a huge system involved in the sensation and control of blood pressure, not only within the kidneys, but all over the body - especially in times of great need. This is in contrast to a smaller system called tubuloglomerular feedback, which you can think of as the system that senses and controls blood pressure and glomerular filtration rate within the kidneys on a moment-by-moment basis. When called upon, this smaller system can also rev up the really big system I'm about to get into. So, what is this really big system?

Could I get a drumroll? The most important system involved in the regulation of systemic blood pressure, renal blood flow and glomerular filtration rate is called the renin-angiotensin-aldosterone system, or (RAAS) for short.

The Release of Renin

When systemic hypotension, or low blood pressure throughout the body, occurs, receptors in your blood vessels called baroreceptors sense this change. Cells of the kidney's juxtaglomerular apparatus get involved as well. Detection by one or both of these mechanisms leads juxtaglomerular cells in the kidneys to release an enzyme called renin. Renin is an enzyme released by the juxtaglomerular cells of the kidneys in response to low blood pressure, causing the transformation of angiotensinogen to angiotensin I.

Angiotensinogen & Angiotensin I

Angiotensinogen is a precursor protein made in the liver for a hormone called angiotensin I. Essentially, renin catalyzes a reaction that converts the angiotensinogen protein into angiotensin I, which is a precursor hormone that is converted to an active hormone called angiotensin II by an enzyme known as angiotensin-converting enzyme in the lungs. Wow, that was a mouthful! Let's break this down.

Here's how to remember what becomes what. Angiotensinogen's purpose is to serve as a precursor to angiotensin I. Angiotensinogen is cleaved, or broken apart, by renin. Since it's broken apart, it gets smaller and becomes shorter in name as well. Therefore, it's now called plain old angiotensin I. Angiotensin I decides to have a little kid and name it after itself. Therefore, when angiotensin I is converted in the lungs by an enzyme called ACE, it becomes angiotensin junior - or more technically, angiotensin II.

Angiotensin I is converted into angiotensin II in the lungs by the enzyme ACE.
ACE

Angiotensin-Converting Enzyme (ACE) & Angiotensin II

It bears repeating that the angiotensin-converting enzyme, or ACE for short, is an enzyme located mainly in the lungs that converts angiotensin I into angiotensin II. Once angiotensin II is made, it can have a big effect on the body. Namely, angiotensin II is a vasoconstrictive hormone that increases systemic blood pressure, renal perfusion pressure and the glomerular filtration rate.

Angiotensin II not only constricts blood vessels all over the body in order to increase systemic blood pressure, it also works in the kidneys in order to maintain blood pressure in the glomerulus so that the glomerular filtration rate stays normal even in the face of low blood pressure.

Control of the Glomerular Filtration Rate (GFR) by the RAAS

Let's see how this works with a familiar example. If you connect a hose to a faucet and turn the faucet on, a certain pressure will be exerted by the water on the walls of the hose. Likewise, blood running through the glomerulus (our hose) does the same thing. If the faucet is turned down a bit due to hypotension, there is less water running through the hose and therefore less pressure being exerted on the hose. If this were to happen in our glomerulus due to hypotension, this would be very bad. We need to maintain pressure in the glomerulus at a certain level if we want to filter our blood enough to stay alive.

To maintain pressure in the glomerulus and therefore keep the glomerular filtration rate steady, angiotensin II constricts both the efferent and afferent arteriole, but with a much greater effect on the efferent arteriole. Remember, the effect of angiotensin II is greater on the efferent arteriole. This means that the blood entering the glomerulus has a much harder time leaving it because the exit is far smaller than the entrance. This causes a backup of blood in the glomerulus, increases the pressure within it and, therefore, keeps the GFR at an appropriate rate.

Angiotensin II constricts the afferent and efferent arterioles.
Angiotensin II

In addition, angiotensin II increases the absorption of sodium in the renal tubule. Since water follows sodium, it increases the amount of fluid in the blood vessels, further causing an increase in blood pressure in addition to the vasoconstriction that already occurred.

Aldosterone

Angiotensin does some other important things that you must remember. It causes the release of a hormone called aldosterone from the adrenal glands. Aldosterone is a hormone that increases the absorption of water from the distal convoluted tubule and collecting duct of the kidney's nephrons.

Aldosterone has many other functions, including the secretion of potassium into urine. However, for this lesson, you should understand that aldosterone causes the absorption of sodium out of the renal tubule's filtrate and into the blood. Since water follows sodium, more water is reabsorbed back into the blood in order to increase the blood pressure.

Anti-Diuretic Hormone (ADH)

As if constricting blood vessels and releasing aldosterone to retain water and sodium weren't enough, angiotensin II also causes the release of a hormone called anti-diuretic hormone, commonly called vasopressin, or ADH for short.

ADH is a hormone released from the posterior pituitary gland that causes an increase in blood pressure. ADH vasoconstricts our blood vessels, which causes increased blood pressure. It also increases water absorption from the distal tubule and collecting ducts. Now that you know what it does, it's easy to remember this because 'anti' in 'anti-diuretic' means 'against,' and 'diuretic' means 'excess urine production' that occurs thanks to water loss. Hence, ADH is against the loss of water in urine from your body!

Vasopressin raises blood pressure by vasoconstricting blood vessels and increasing water absorption.
Vasopressin

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Additional Activities

Word Puzzle Fun

When learning is fun, it is easier to maintain the information learned. In this activity, you will create a fun word puzzle to review the information you have learned related to the renin angiotensin aldosterone system (RAAS).

Materials

  • Grid paper
  • Pencil / pen
  • Eraser
  • Ruler

Instructions

  • Begin your project by deciding on what type of word puzzle you would like to create. A couple of common ideas are:
    • Cross-word puzzles
    • Word searches
  • Next, you will want to decide how many concepts you would like to include in your puzzle. For the sake of this activity, please include 10-20 words/concepts in your review puzzle.
  • Now, write clues that will lead to words or phrases to be used within the puzzle. For example:
    • This is a precursor protein made in the liver. (Answer: Angiotensinogen)
    • RAAS stands for _____-angiotensin=aldosterone system. (Answer: Renin)
    • The _____ feedback system is the smaller system that controls blood pressure? (Answer: Tubuloglomerular feedback system)
  • It is recommended that you create these types of clues leading to concepts and terms from the lesson for word searches as well as cross-word puzzles in order to maintain a high level of academic value in your activity sheet.
  • Your final task is to create the puzzle area itself.
    • Write out the answers to your clues on a piece of grid paper (one letter per square).
    • Cut out each answer.
    • Now, arrange your answers into a puzzle with words intersecting at common letters.
      • Remember to allow for about half of your words to be vertical and half to be horizontal.
  • The next step depends on the type of puzzle you are creating:
    • Cross-word: Use the ruler to draw boxes on another sheet of paper to match the shape of your arranged answers in their puzzle form.
      • Create an answer key by copying your blank puzzle boxes and filling in the correct answers or just taping the arranged, cut-out words together in the correct format.
    • Word search: Use a new sheet of grid paper and first write in the words as you have arranged them with the cut out answers.
    • Now, draw a large square that encompasses all of your letters and fill in any empty grid boxes with random letters.
      • Make an exact copy of this completed sheet to use as an answer key (circle the correct words).
  • Don't forget to write your clues at the bottom of your puzzle grid.

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