The Uterine Cycle: Phases and Endometrial Changes

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  • 0:05 PMS
  • 1:05 The Uterine Cycle
  • 2:05 Phases
  • 4:01 Hormone Cycles
  • 6:34 Lesson Summary
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Lesson Transcript
Instructor: Heather Adewale

Heather has taught reproductive biology and has researched neuro, repro and endocrinology. She has a PhD in Zoology/Biology.

Just like a woman's ovaries go through the monthly cycle of recruiting eggs, her uterus also goes through a monthly cycle as it prepares for the possible implantation of a fertilized egg. This lesson will introduce you to the phases and hormones of the female's uterine cycle.


I know you've all heard of PMS, right? You know - premenstrual syndrome. I know you guys may think it's just those weird monthly mood swings that females go through where they're laughing one minute and crying the next. And girls, I know what you're thinking, 'What mood swings?', right? Or maybe you're remembering those cramps and achy muscles you have to deal with for a few days every month. But did you know about the physiological reason for it? Have you ever thought about what the words actually mean?

Well, 'pre' obviously means 'before' and 'menstrual' means the menstrual cycle, but what about the word 'syndrome'? Well, 'syndrome' is used to classify PMS as a condition. However, despite what you may think, not every woman experiences symptoms of PMS, and for those that do, their symptoms vary widely. So, what exactly is this menstrual cycle that PMS precedes?

The three layers of the uterine wall
Three Layers of Uterus

The Uterine Cycle

The uterine cycle (menstrual cycle) is the monthly series of changes that the female's uterus, or uterine tissue, undergoes in preparation for the implantation of a fertilized egg. And, like all other cycles in biology, there're different phases - three in this case.

Each phase involves changes in the uterine wall, which is made up of three different layers. There's the outer perimetrium, the middle and muscular myometrium (that's the thickest layer), and the inner and thinner endometrium.

But only one of these layers undergoes the changes during the uterine cycle, and that's the endometrium. The endometrial tissue itself is also made up of two layers: there's the basilar zone, which attaches the endometrium to the underlying myometrium, and the functional zone, which is the part that changes throughout the uterine cycle.


The first phase of the cycle is menses. Menses is the beginning of the uterine cycle, when the unneeded uterine tissue sheds. This is going to be followed by the proliferative phase, which is a period of tissue regeneration, and then, last but not least, the secretory phase, where the arteries and glands supplying the tissue regenerate. All together, the uterine cycle takes an average of 28 days, but this can vary from 21-35 days based on the individual female.

The three phases of the uterine cycle
Phases of Uterine Cycle

Each month, the uterus prepares for the possibility of fertilization. It does so by preparing or creating a new layer of endometrial tissue. Remember how we said the uterus was made up of three layers? Well, you can think of the layers this way: the endometrial layer is the layer that's changed every month - kind of like the sheets on a bed. And the myometrial layer - that's like the comforter on your bed, and that doesn't get changed as often, and, in the case of the uterus, the myometrium doesn't get changed at all. Each month, just like you would put new sheets on a bed, the endometrium prepares new layers of tissue.

If fertilization occurs, the fertilized oocyte, or egg, travels to the uterus, where it implants itself into the uterine wall - kind of like it's nestling itself under the sheets of a bed. From there, it continues its development for the next nine months of pregnancy.

If fertilization does not occur, the uterus has to start all over again! It does this first by shedding all of its tissue in the functional zone - that's the menses phase - and then rebuilding it during the proliferative phase. That takes about two weeks. Once rebuilt, the secretory phase helps finish up the final preparations, just in case the next oocyte is fertilized.

Hormone Cycles

Uterine tissue isn't the only thing that changes during the cycle. The female's steroid hormone levels also change - most importantly, the hormones estrogen and progesterone.

A fertilized oocyte will implant itself into the uterine wall
Endometrium Like Sheets

Both of these hormones are produced by the female's ovaries during different parts of her ovarian cycle. You see, at the same time the uterus is progressing through its cycle, the ovaries are progressing through a cycle of their own, called the ovarian cycle. This cycle is also monthly, and it involves the stages of oocyte growth and development, preparing the oocyte for ovulation and fertilization.

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