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What is Prothrombin Time? - Definition & Normal Range

What is Prothrombin Time? - Definition & Normal Range
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  • 0:04 Thrombus or Coagulation
  • 0:37 Prothrombin Time: Defined
  • 1:04 Normal Prothrombin Time
  • 3:05 Blood Composition
  • 3:37 Normal Thrombus Formation
  • 4:32 Lesson Summary
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Lesson Transcript
Instructor: Sarah Phenix
In this lesson, we will explore what prothrombin time means. Next, we will review the normal range for prothrombin time, look at the components of blood, and then determine how these components work together to form blood clots.

Thrombus or Coagulation

If you've ever watched a surgical TV show, you've probably heard the doctors call for a tool called a hemostat, or surgical forceps used to clamp blood vessels. Interestingly enough, the term 'hemostat' means to stop ('stat') bleeding ('hemo'). Our bodies have their own natural hemostatic ability to form blood clots, also known as coagulation or a thrombus. So what does any of this have to do with 'prothrombin time,' you ask? Well, lucky for you, that's the very question we're here to answer.

Prothrombin Time: Defined

Prothrombin time (PT) is pretty much what it sounds like. It's a measure of the amount of time that it takes for your blood to produce a thrombus or a blood clot. So why might this be important? Well, blood clots close exposed vessels by forming a scab on your skin. Simply put, blood clots keep us from bleeding out when we get a cut or scrape. Therefore, a prothrombin time test evaluates whether or not your blood clots at a normal rate.

Normal Prothrombin Time

A prothrombin time test may take the form of either a finger prick or a blood draw. There are actually a variety of tests that laboratories can use to calculate a patient's prothrombin time, each of which operates on its own scale of what a normal range is, making comparing results between laboratories really hard. You're essentially comparing apples and oranges by comparing results between laboratories. Consequently, an international standard, known as the International Normalized Ration (INR) was developed, which provides a universal normalized prothrombin range accounting for any influence that different PT tests may have on the test results. The normalized INR range allows values between laboratories to be readily compared without concern for accounting for their different testing methods. Thanks to this much simpler INR conversion, most labs will now only report using the INR format, which dictates a normal range of 0.8 to 1.1 and loosely translates to 11 to 13 seconds.

What does this time frame mean? Well, it means that it should take anywhere between 11 and 13 seconds for a drop of a healthy person's blood to coagulate. Now, keep in mind that blood thinners, like aspirin, can lengthen the prothrombin time. This is why you may have noticed people at risk for heart attack or stroke taking aspirin. It thins their blood to help avoid blood clot formation. If a clot is formed and released into the bloodstream, it could result in a blockage leading to a heart attack or stroke.

A longer-than-normal PT test could indicate a range of issues, including a vitamin K deficiency in your diet. Vitamin K is required by the liver to produce prothrombin, which is one of five clotting proteins that a PT test evaluates. A longer PT test could also indicate cirrhosis of the liver, or liver disease, as the liver produces each of the five clotting factors that a PT test evaluates. To better understand what this all means, let's go back and take a look at the basic components of blood and the process of clotting

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