Wound Granulation: Definition, Stages & Care

Instructor: Dan Washmuth

Dan has taught college Nutrition and Anatomy courses for several years. He has a B.S. in Exercise Physiology from Furman University and a M.S. in Dietetics & Nutrition from Florida International University. He is a Registered Dietitian (RD) and a Certified Exercise Physiologist (EP-C)

Wound granulation refers to the new tissues and blood vessels that grow in a wound during the healing process. Learn about the definition, stages, and care for wound granulation.

Wound Granulation

Mike is a 12-year-old boy who loves to play baseball. During a recent game, Mike hit the ball deep into the outfield, past the opposing players. Mike ran as fast as he could and slid safely into second base before the other team could get him out. However, during his slide, Mike scraped his knee badly, resulting in a large wound.

When Mike got home, his mom helped him clean the wound and cover the wound with a bandage. Over the next several days, Mike noticed that his cut began turning bright pink, bumpy, soft, and moist. Mike asks his mom, who is a nurse, what was happening to his wound. His mom told him that his wound was granulating, which is a fancy word for growing new skin.

Wound granulation is an important part of the healing process.
scraped knee


Wound granulation is the development of new tissue and blood vessels in a wound during the healing process. During wound granulation, the wound may have several different physical characteristics, which include:

  • Bring pink or red in color
  • Soft
  • Bumpy and raised above the skin's surface
  • Wet or moist

The granulation tissue is also usually painless during this stage of wound healing.

Wound granulation may be pink or reddish in color, moist, bumpy, and raised.


The wound granulation process begins with blood vessels supplying the wound with blood. Blood contains oxygen and other nutrients required for proper wound healing. These blood vessels not only supply the wound with oxygen and nutrients, but they also help to take away waste products from the wound.

Once blood flow to the wound is established, fibroblasts will appear in the wound. Fibroblasts are cells that produce connective tissues throughout the body, such as collagen, that is required for the formation of new skin and blood vessels.

While the fibroblasts are laying down new tissues, immune cells help protect the wound against bacteria, viruses, and other organisms that might cause infection and delay the healing process. These immune cells include macrophages and neutrophils.


In order to help promote the healing process and wound granulation, it is important to keep a wound clean and moist. Cleaning a wound can be done by using water and a mild soap, or even just water alone. It is important not to scrub the wound since scrubbing may cause further damage to the tissues.

Once the wound is cleaned, it is a good idea to apply an antibiotic cream to the wound. The antibiotic cream will help to prevent infection as well as help keep the wound moist. A moist wound bed is the best wound environment for proper healing.

It is also important to keep a wound covered with a bandage. Covering a wound with a bandage will help protect the wound and keep it clean. It will also help to keep the moisture in the wound which will improve the healing process.

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