Haplosufficient Genes and Inheritance Patterns of Lethal Alleles


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A person who has one functional copy of the HEXA gene and one Tay-Sachs allele should have about what percentage of beta-hexosaminidase A enzyme compared to what is found in most individuals in the human population?

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1. Why are there not any well-known, highly penetrant, dominant disorders that are lethal before sexual maturity?

2. What is haplosufficiency?

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About This Quiz & Worksheet

Tay-Sachs Disease is an example of a lethal recessive allele disorder, and this quiz will test your understanding of the relationship between Tay-Sachs Disease and haplosufficient genes.

Quiz & Worksheet Goals

The materials will help you study the following:

  • Why Tay-Sachs Disease is recessive
  • Definition of haplosufficiency
  • Why there aren't any lethal dominant disorders before sexual maturity
  • Comparative percentages of beta-hexosaminidase A enzyme

Skills Practiced

You'll get an opportunity to practice the following skills:

  • Making connections - use understanding of the concept of inheritance patterns and dominant lethal alleles
  • Interpreting information - verify that you can read information regarding Tay-Sachs Disease and interpret it correctly
  • Information recall - access the knowledge you've gained regarding the percentage of beta-hexosaminidase A enzyme a person could have under certain circumstances
  • Defining key concepts - ensure that you can describe the situation where a single copy of a functional gene is not enough to maintain normal function

Additional Learning

You can learn more about this topic by checking out the accompanying lesson called Haplosufficient Genes and Inheritance Patterns of Lethal Alleles. In that lesson, you'll cover the following objectives:

  • Define Tay-Sachs Disease
  • Discuss why lethal disorders are recessive
  • Compare and contrast haplosufficiency with haploinsufficiency
  • Review inheritance patterns of deadly alleles