Inhibitors of Protein Synthesis: How Antibiotics Target the Bacterial Ribosome


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A patient comes into the hospital with a severe intestinal infection. She says she is a technician in a biology lab that works with the Gram-negative bacterium Shigella flexneri, which you know causes dysentery. At the moment, your hospital has run out of all antibiotics except protein synthesis inhibitors. Which of these drugs would NOT be a good choice to give your patient?

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1. Which of these antibiotics prevents tRNAs from attaching to the A site of the ribosome?

2. How do eukaryotic and bacterial ribosomes differ?

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About This Quiz & Worksheet

This quiz and worksheet combo will help you quickly assess your understanding of the roles and structures of inhibitors of protein synthesis. You will be quizzed on antibiotics.

Quiz & Worksheet Goals

This quiz/worksheet combo can help you review:

  • The prevention of tRNA's attachment to ribosomes
  • Differences between bacterial ribosomes and eukaryotic ribosomes
  • The polypeptide chain's emergence
  • Misread mRNA sequences

Skills Practiced

This quiz and worksheet can be used to help you practice the following skills:

  • Information recall - access the knowledge you have gained regarding protein synthesis
  • Knowledge application - use your knowledge to answer questions about polypeptides
  • Distinguishing differences - compare and contrast main topics, such as eukaryotic and bacterial ribosomes

Additional Learning

Antibiotics inhibit the protein synthesis of bacteria in many different ways. To understand this process, you'll need to know the makeup of bacterial ribosomes and antibiotics in detail. Learn more about these concepts by reading the lesson called Inhibitors of Protein Synthesis: How Antibiotics Target the Bacterial Ribosome. The lesson helps you:

  • Compare and contrast eukaryotic and bacterial ribosomes
  • Identify inhibitors of protein synthesis
  • Determine the roles of inhibitors of protein synthesis
  • Detail characteristics of different types of antibiotics