Irreversible Cellular Injury and Death: Types and Causes


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A granuloma is a collection of many immune cells, including macrophages, that occurs as a result of a long-standing disease process. Since you know that granulomas are associated with chronic, or long term, disease processes, then you can deduce that some granulomas are most likely to be associated with which kind of necrosis?

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1. Barry has an area of skin that has turned a dark, reddish-black. When the doctor looks at the affected cells under a microscope, they have preserved their cellular architecture but the proteins are denatured. He tells Barry that he has gangrene. What form of necrosis does Barry have?

2. Immune mediated vasculitis is an inflammation of blood vessels as a result of an aberrant immune system. Which type of necrosis would be most likely associated with this condition?

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About This Quiz & Worksheet

What are the physical characteristics and causes of certain types of cell death? In this quiz/worksheet combo, you will be tested on terms used to describe these cell deaths and injuries.

Quiz & Worksheet Goals

In these assessments you'll be tested on the terms used to describe the various types of necrosis, including:

  • What some granulomas have
  • Type that preserves the outlines of cells and has a semi-firm appearance
  • What type is most similar to the enzymatic degradation in a zit
  • Where fat may be converted to soap
  • Would be associated with immune mediated vasculitis
  • Most common type in the central nervous system
  • Type associated with ischemia, or other causes of hypoxia
  • Type related to an untreated inflammation of the pancreas

Skills Practiced

This worksheet and quiz will allow you to test the following skills:

  • Reading comprehension - ensure that you draw the most important information from the lesson on the types of cell death known as necrosis
  • Defining key concepts - ensure that you can accurately define main phrases, such as caseous necrosis and fibrid necrosis
  • Distinguishing differences - compare and contrast coagulation necrosis and liquefactive necrosis
  • Information recall - access the knowledge you've gained regarding various types of necrosis

Additional Learning

To learn more about this topic, review the accompanying lesson called Irreversible Cellular Injury and Death: Types and Causes. This lesson will help you learn how to:

  • Use an example of the wear and tear on a car to illustrate cellular injury and death
  • Discuss causes of cell injury
  • Define necrosis
  • Identify and describe types of necrosis