Lethal Alleles: Definition & Examples


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Tay-Sachs disease is caused by:

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1. A _____ causes Huntington's Disease.

2. Two heterozygous yellow mice were crossed. They were yellow in color, coded for by an agouti allele, which is dominant to their other allele that causes a grey color in mice. The offspring showed a 2:1 ratio of yellow to grey color. What do these results suggest?

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About This Quiz & Worksheet

Your understanding of lethal alleles and their effects will be assessed in this quiz and accompanying worksheet. Practice questions look at illnesses causes by lethal alleles, the difference between recessive and dominant lethal alleles, and the role of the agouti gene in the discovery of lethal alleles.

Quiz & Worksheet Goals

Test your comprehension of lethal alleles through this quiz. Questions will examine:

  • Cause of Tay-Sach's disease
  • Cause of Huntington's Disease
  • The offspring of two crossed yellow mice
  • Results of pairing two flies that may have a recessive lethal allele
  • The agouti gene

Skills Practiced

This assessment will test the following skills:

  • Making connections - understanding of the concept of the agouti gene in genetic research
  • Knowledge application - Use your knowledge to answer questions about the causes of Tay-Sach's disease and Huntington's Disease
  • Information recall - access the knowledge you've gained regarding lethal alleles

Additional Learning

Learn more about lethal alleles in the lesson titled, Lethal Alleles: Definition and Examples. Topics include:

  • The role of the acouti mice in the discovery of lethal alleles
  • Recessive lethal alleles
  • Dominant lethal alleles