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Ch 4: The Molecular & Chromosomal Basis of Inheritance

About This Chapter

Watch these video lessons and learn about the structure and purpose of DNA, differences between DNA and RNA, and DNA replication. Get information on genetic engineering and DNA technology.

The Molecular & Chromosomal Basis of Inheritance - Chapter Summary

Our lessons in this chapter examine the basics of inheritance, including the chemical and physical structure of DNA. Learn about types of RNA and models of DNA replication. See what happens when helicase unwinds the DNA double helix and look at what initiates DNA replication.

Other lessons discuss transcription regulation in eukaryotes and the definition and uses of genetic engineering. You'll also learn about uses and problems with DNA technology. After completing all these lessons, you should be able to:

  • State the chemical structures of nucleic acids and phosphodiester bonds
  • Discuss adenine, guanine, cytosine, thymine and complementary base pairing
  • Describe the double helix structure and hereditary molecule of DNA
  • Report on the types of RNA and list differences in RNA and DNA
  • Describe the DNA replication process and the conservative, semi-conservative and dispersive models of DNA replication
  • Explain the practical uses for DNA technology and associated safety concerns

These lessons are led by expert instructors who make learning fun, while teaching you what you need to know. Each lesson is accompanied by quizzes that let you test your knowledge. If you need to review certain parts of the lesson, the timeline's jump feature makes it quick to go back to that specific topic without re-watching the whole lesson.

12 Lessons in Chapter 4: The Molecular & Chromosomal Basis of Inheritance
Test your knowledge with a 30-question chapter practice test
DNA: Chemical Structure of Nucleic Acids & Phosphodiester Bonds

1. DNA: Chemical Structure of Nucleic Acids & Phosphodiester Bonds

In this lesson, you'll discover what nucleotides look like and how they come together to form polynucleotides. We'll also explore nucleic acids and focus on DNA in particular.

DNA: Adenine, Guanine, Cytosine, Thymine & Complementary Base Pairing

2. DNA: Adenine, Guanine, Cytosine, Thymine & Complementary Base Pairing

Learn the language of nucleotides as we look at the nitrogenous bases adenine, guanine, cytosine and thymine. Armed with this knowledge, you'll also see why DNA strands must run in opposite directions.

DNA: Discovery, Facts, Structure & Function in Heredity

3. DNA: Discovery, Facts, Structure & Function in Heredity

This lesson will help you to navigate the twists and turns of DNA's structure. We'll also clue you in on the amazing discoveries that put this nucleic acid in the limelight as the molecule of heredity.

Differences Between RNA and DNA & Types of RNA (mRNA, tRNA & rRNA)

4. Differences Between RNA and DNA & Types of RNA (mRNA, tRNA & rRNA)

In this lesson, you'll explore RNA structure and learn the central dogma of molecular biology. Along the way, you'll meet the three types of RNA and see how the cell uses them most effectively.

What Is DNA Replication? - Conservative, Semi-Conservative & Dispersive Models

5. What Is DNA Replication? - Conservative, Semi-Conservative & Dispersive Models

How do we know that DNA replication is semi-conservative? How do we know it's not conservative or dispersive? Let's follow the famous experiment by Meselson and Stahl to find out!

How Helicase Unwinds the DNA Double Helix in Preparation for Replication

6. How Helicase Unwinds the DNA Double Helix in Preparation for Replication

How does semi-conservative replication begin? Discover how DNA helicase creates a replication fork to unwind the complicated DNA molecule and allow daughter strands to form on the parental template.

How DNA Polymerase and RNA Primase Initiate DNA Replication

7. How DNA Polymerase and RNA Primase Initiate DNA Replication

How do enzymes assist in starting DNA replication? In this lesson, we explore the work of a contributing enzyme, DNA polymerase, and learn how the RNA primer is made by the action of RNA primase.

DNA Replication: The Leading Strand and DNA Polymerase Activities

8. DNA Replication: The Leading Strand and DNA Polymerase Activities

How does replication occur in the antiparallel DNA molecule? In this lesson, explore the significance of the leading and lagging strands, and learn how Okazaki fragments and RNA ligase make DNA replication possible.

DNA Replication: Review of Enzymes, Replication Bubbles & Leading and Lagging Strands

9. DNA Replication: Review of Enzymes, Replication Bubbles & Leading and Lagging Strands

Feeling lost in the thorny details of DNA replication? This lesson provides an overview of semi-conservative replication, with a focus on putting together all of the concepts involved. We'll review the work of each enzyme on our way to completing the big picture of DNA replication.

Examples of Transcription Regulation in Eukaryotes

10. Examples of Transcription Regulation in Eukaryotes

Transcription is more complicated than just turning a gene 'on' or 'off' like a light switch. In this lesson, you'll learn how eukaryotic transcription is regulated through the use of DNA regulatory regions, DNA methylation, and chromatin modification.

Genetic Engineering & DNA Plasmid

11. Genetic Engineering & DNA Plasmid

This lesson will discuss what a GMO is, and how DNA plasmids are used in genetic engineering. The lesson will include these important features of plasmids: a multiple cloning site, an origin of replication, and a selectable marker.

Practical Applications & Safety Concerns of DNA Technology

12. Practical Applications & Safety Concerns of DNA Technology

Our discovery of DNA was a big deal, but what technologies has it led to? And could they be dangerous? Learn about DNA technology, and then test your knowledge with a quiz.

Chapter Practice Exam
Test your knowledge of this chapter with a 30 question practice chapter exam.
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Practice Final Exam
Test your knowledge of the entire course with a 50 question practice final exam.
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