About This Chapter
Below is a sample breakdown of the Transcription and Translation chapter into a 5-day school week. Based on the pace of your course, you may need to adapt the lesson plan to fit your needs.
|Day||Topics||Key Terms and Concepts Covered|
|Monday||The Central Dogma and Transcription||Explanation of the central dogma, including the transfer of genetic information from DNA to RNA; role of RNA polymerase in transcribing DNA into RNA and the three stages of transcription|
|Tuesday||Regulation of Gene Expression and Operons||Description of transcriptional induction and repression of operons or linked genes; overview of how operons oversee the transcription process in prokaryotic cells|
|Wednesday||Genetic Codes and RNA Processing in Eukaryotic Cells||Parts and products of eukaryotic cells, including exons and introns; spliceosomes, codons and role of genetic code in translating RNA into amino acids|
|Thursday||Codon Recognition||Genetic code of messenger RNA (mRNA), the RNA codon chart, role of transfer RNA (tRNA) in matching amino acids with codons and definition of the anticodon|
|Friday||Genetic Translation: Ribosomes, Peptide Bonds and Proteins||Polypeptide assembly, structure of ribosomes and steps involved in translating mRNA into protein, including initiation, elongation and termination|
1. Protein Synthesis in the Cell and the Central Dogma
Learn the story of the central dogma and how it relates to protein synthesis. We'll use a simple analogy to explore the roles of transcription and translation in building protein from the DNA code. In this lesson, we'll also introduce the concept of a gene.
2. Transcription of Messenger RNA (mRNA) from DNA
In this lesson, you will gain a thorough understanding of how transcription works. We will investigate how DNA is transcribed into RNA with the help of a promoter and RNA polymerase. Learn the purpose of messenger RNA and explore the three phases of transcription.
3. Regulation of Gene Expression: Transcriptional Repression and Induction
Do our genes work the same way all the time? How do we regulate the expression of our genes? Explore the various ways organisms control gene transcription through repression and induction of operons.
4. How An Operon Controls Transcription in a Prokaryotic Cell
Is gene regulation really as simple as flipping a switch? What are the parts of an operon, and how do they function to control gene transcription? We'll study the lac operon to answer these questions.
5. RNA Processing in a Eukaryotic Cell: Splicing of Introns & Exons
In this lesson, we'll explore the unique considerations for gene regulation in the eukaryotic cell. We'll walk through RNA splicing of introns and exons and the addition of the 5' cap and poly(A) tail.
6. What Is the Genetic Code That Translates RNA Into Amino Acids?
How is RNA translated into a series of amino acids? Learn the language of the genetic code, explore a codon dictionary, and discover some basics of genetics in this lesson on translation.
7. Making Sense of the Genetic Code: Codon Recognition
Explore the genetic code and how it is translated into a polypeptide. We'll practice using the RNA codon chart and learn the basics of codon recognition.
8. Codon Recognition: How tRNA and Anticodons Interpret the Genetic Code
How does codon recognition work at the molecular level? Can you use tRNA and anticodons to decipher the genetic code? Learn the mechanics of codon recognition and build a polypeptide from a sample genetic code.
9. The Role of Ribosomes and Peptide Bonds in Genetic Translation
Ribosomes play a major role in the process of genetic translation. In this lesson, learn about the structure of ribosomes and how peptide bonds help to create chains of amino acids.
10. Translation of mRNA to Protein: Initiation, Elongation & Termination Steps
Translation, the second part of the central dogma of molecular biology, describes how the genetic code is used to make amino acid chains. In this lesson, explore the mechanics involved in polypeptide synthesis. Learn the three major steps of translation as you watch tRNA, mRNA, and ribosomes go to work.
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